High Purity 99.0%min. 9-Methyl-9h-Beta-Carboline CAS 2521-07-5 9-Me-Bc Powder Nootropics Product name: 9-Methyl-9H-beta-carboline;
CAS No.: 2521-07-5;
Synonyms: 9H-Pyrido(3,4-b)indole, 9-methyl-;9-Methyl-9H-pyrido(3,4-b)indole;
9-methyl-beta-carboline
Molecular Formula: C12H10N2;
Molecular Weight: 182.2212;
Density: 1.17g/cm3
Boiling point: 367.3°C at 760 mmHg;
Flash point: 175.9°C;
Refractive index: 1.658;
Capacity: 500kgs per month
Source: synthetic
Purity (HPLC) >99.0%
Packing: As per client's requirements
Minimum Order Quantity: 1kg
Storage: Store in cool & dry place, Keep away from strong light and heat for 2 years
Product Description: 9-Me-BC is a methylated derivative of β-carboline with the molecular formula C12H10N2.
It may be prepared by preforming the Eschweiler-Clarke reaction on freebase β-carboline.
9-Me-BC is a known inhibitor of monoamine oxidase A and monoamine oxidase B, and has been proposed for further investigation in the treatment of Parkinson's disease.
Function and Application: β-Carbolines (BCs) belong to the heterogenous family of carbolines, which have been found exogenously, that is, in various fruits, meats, tobacco smoke, alcohol and coffee, but also endogenously, that is, blood, brain and CSF. These exogenous and endogenous BCs and some of their metabolites can exert neurotoxic effects, however, an unexpected stimulatory effect of 9-methyl-β-carboline (9-me-BC) on dopaminergic neurons in primary mesencephalic cultures was recently discovered. The aim of the present study was to extend our knowledge on the stimulatory effects of 9-me-BC and to test the hypothesis that 9-me-BC may act as a cognitive enhancer.
We found that 10 days (but not 5 days) of pharmacological treatment with 9-me-BC (i) improves spatial learning in the radial maze, (ii) elevates dopamine levels in the hippocampal formation, and (iii) results after 10 days of treatment in elongated, more complex dendritic trees and higher spine numbers on granule neurons in the dentate gyrus of 9-me-BC-treated rats.
Our results demonstrate that beyond its neuroprotective/neurorestorative and anti-inflammatory effects, 9-me-BC acts as a cognitive enhancer in a hippocampus-dependent task, and that the behavioral effects may be associated with a stimulatory impact on hippocampal dopamine levels and dendritic and synaptic proliferation.
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