High Purity 99.0%Min. Dsip Delta Sleep Inducing Peptide with Best Price
Dsip Details:
Alias: Delta Sleep Inducing Peptide
CAS: 62568-57-4
Sequence: TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU
MF: C35H48N10O15
MW: 848.813620
Purity: 99%
Specification: 2mg/vial
Appearance: White Lyophilized Powder
Place of Origin: China
Standard: USP
Certification: SGS
Method of Analysis: HPLC
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18 C. Upon reconstitution of the peptide it should be stored at 4 C between 2-21 days and for future use below -18 C.
Dsip Usage:
DSIP (Delta Sleep-inducing Peptide) is a neuropeptide found in the hypothalamus, pituitary, and adrenal glands. Its isolation has allowed for extensive research which has found several possible primary and peripheral roles of this peptide. First, DSIP has been shown to induce sleep. Second, it may have benefits as an analgesic in treatment of chronic pain, sometimes as an adjunct treatment. Third, DSIP has been shown to block release and decrease levels, stimulate LH release, and act as an inhibitor of the secretion of somatostatin. The source of production of DSIP is yet unknown; It may be produced in the central nervous system or in a peripheral organ. It is thought to pass
Through the blood-brain barrier (BBB) more easily than most known neuropeptides. As mentioned, DSIP has shown positive results in inducing slow-wave EEG (sleep). It has been shown to help treat narcolepsy and restore disturbed sleep patterns to normal sleep rhythms.
DSIP Function
Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stabilityand through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIPantiserum and antibodies.
Roles in endocrine regulation
Decreases basal corticotropin level and blocks its release.
Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.
Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.
Delta sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have been contradictory.