High Purity 99.0%min. Pramlintide Acetate Lyophilized powder Peptide CAS NO.: 196078-30-5; 151126-32-8 Research Chemical
Product Information:
INCI Name: Pramlintide Acetate
Cas No: 196078-30-5/151126-32-8
Molucular Formula: C171H267N51O53S2
Molecular Weight: 3949.44
Sequence:Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2(Cys2&Cys7 bridge)
Purity: >99%
Source: Synthetic
Grade: Cosmetic
Stability: Stable
Solubility: Slightly soluble in water
Formulation: Available for your reference, please contact us
MSDS and COA: Available for your reference, please contact us
Appearance: White Lyophilized powder
Storage:After reconstitution store at 2°C - 8°C
Description:
Pramlintide acetate is an injectable human amylin analog that has been launched for the treatment of both type 1 and type 2 diabetes. While it is also a 37-amino acid peptide, it differs from its parent predecessor by the substitution of Ala-25, Ser-28, and Ser-29 with prolines. Not only do these modifications improve the solubility of the peptide, they also eliminate the aggregation observed with amylin, resulting in a stable synthetic analog with retention of biological activity that is suitable for pharmaceutical use.
As an indication of potency, Pramlintide acetate inhibits the binding of radioiodinated rat amylin to rat nucleus accumbens membranes with a Ki value of 23 pM.
Usage:
Pramlintide acetate is an analogue of human amylin used in the treatment of dependent diabetes.
Clarify:
Our peptides is just for Reseach&Lab use,not used on Human body.
The potential efficacy and application involved in the product introduction are all from the published literature, which has not been evaluated by the State Food and Drug Administration, and are only for reference, not for actual basis.
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